Department of Biological Sciences

Dodge Hall Rm 375
118 Library Dr
Rochester, MI 48309-4479
(location map)
(248) 370-3550
fax: (248) 370-4225
biology@oakland.edu

song

Mi Hye Song

Mi Hye Song
Associate Professor, Ph.D.
344 DH
(248) 370-4494
Lab location: 333 DH
Lab phone: (248) 370-3569

Courses:

BIO 3232 Biochemistry I
BIO 4211 Molecular Biology Laboratory
BIO 5920 Directed Readings in Biology

Research:

Centrosome regulation: Centrosomes are the primary microtubule-organizing centers (MTOCs) in animal cells, which play an instrumental role in cell polarity, intracellular transport, cell motility, and bipolar spindle assembly. While not absolutely required for mitosis, centrosomes normally play a key role in establishing bipolar spindles. Thus, precise regulation of centrosome assembly is crucial for the correct segregation of chromosomes as cells divide. Genomic instability, a feature of many cancers, is often associated with aberrant centrosomes. Recent studies demonstrated that extra centrosomes alone suffice to promote genomic instability via erroneous attachment of chromosome to microtubules, which is mediated by multipolar intermediates. An understanding of the molecular and genetic mechanisms of centrosome assembly should aid our knowledge of human diseases in which this process goes awry. Despite dramatic recent progress, we are still far from a full comprehension of centrosome biogenesis and its link to the cell cycle. Our laboratory is applying a combination of biochemistry, cell biology, genetics, proteomics and quantitative imaging to the study of centrosome biology in the nematode Caenorhabditis elegans model.

Check out this video about Dr. Song's research on YouTube.

Selected Publications:

Medley*, J.C., DeMeyer*, L.E., Kabara*, M.M. and M.H. Song. (2017). APC/CFZR-1 controls SAS-5 levels to regulate centrosome duplication in Caenorhabditis elegans. G3: Genes, Genomes, Genetics  10.1534/g3.117.300260.

DeMeyer*, L., and M.H. Song. (2017). Localization of tbg-1 mRNAs and GFP::TBG-1 protein in early C. elegans embryos. microPublication Biology. DOI: 10.17912/W2CW8H.

Song, M.H, J. C.Medley* and J.Y. Kuwada. (2017). The Zebrafish curly fry mutation is required for proper centrosome and mitotic spindle assembly. Zebrafish 14(4): 311-321. DOI: 10.1089/zeb.2017.1427.

Medley*, J.C., M.M. Kabara*, M.C. Stubenvoll*, L.E. DeMeyer* and M.H. Song. (2017). Casein Kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in C. elegans embryos. Biology Open 6: 17-28. DOI: 10.1242/bio.022418. Selected for the Biology Open cover photo.

Stubenvoll*, M.D., J. C. Medley*, M. Irwin* and M.H. Song. (2016). ATX-2, the C. elegans ortholog of human Ataxin-2, regulates centrosome size and microtubule dynamics. PLoS Genetics 12(9):e1006370. DOI: 10.1371/journal.pgen.1006370.

Images selected for MRC London Institute of Medical Science's Biomedical Picture of the Day on January 10, 2017.

*OU student