Department of Biological Sciences

Dodge Hall Rm 375
118 Library Dr
Rochester, MI 48309-4479
(location map)
(248) 370-3550
fax: (248) 370-4225

Lan Jiang

A head shot of Lan Jiang

Lan Jiang
Professor, Ph.D.
322 DH
(248) 370-3552
Lab location: 321 DH, 323 DH
Lab phone: (248) 370-3549 


BIO 3130 Developmental Biology
BIO 3210 Biology of the Cell
BIO 3400 Genetics

Research : Mechanisms of biological tube formation in Drosophila tracheal system

Biological tube formation is a developmental process required for the formation of the respiratory, vascular and glandular systems of the body. Defects in tube formation result in numerous human diseases including polycystic kidney disease, atherosclerotic heart disease and cancer. The Drosophila trachea system is a complex interconnected tubular network that delivers oxygen to every cell of the body. It is an excellent model system to study the molecular basis of cell migration, cell recognition, cell adhesion and branch fusion during tube formation. Dr. Jiang's work is focused on studying the regulation of tracheal gene expression and how tracheal-expressed genes control the complex cellular behaviors that result in the formation of a continuous tubular network. Current projects in her lab focus on 1) using molecular biology techniques to determine minimal regulatory regions of tracheal-expressed genes to identify potential direct regulators, 2) using expression profiling and cell-separation techniques to isolate tracheal cells and examine gene expression changes at different developmental time-points, 3) using genetics to understand the role that tracheal genes play during the development and function of the tracheal system.

Selected Publications:

Scholl*, A., M.J. O'Brien*, R.R. Chandran* and L. Jiang. (2019). The novel gene apnoia regulates Drosophila tracheal tube size. Developmental Dynamics 248(6): 477-487. DOI: 10.1002/dvdy.29.

Chandran*, R.R., A. Scholl*, Y. Yang and L. Jiang. (2018). rebuff regulates apical luminal matrix to control tube size in Drosophila trachea. Biology Open 7(9): bio036848. DOI: 10.1242/bio.036848.

Scholl*, A., Y. Yang, P. McBride, K. Irwin and L. Jiang. (2018). Tracheal expression of Osiris gene family in Drosophila. Gene Expression Patterns 28: 87-94. DOI: 10.1016/j.gep.2018.03.001.

Iordanou* E., R. Chandran, Y. Yang, M. Essak, N. Blackstone and L. Jiang. (2014). The novel Smad protein expansion regulates receptor tyrosine kinase pathway to control Drosophila tracheal tube size. Developmental Biology 393:93-108. DOI:  10.1016/j.ydbio.2014.06.016.

Chandran*, R.R., E. Iordanou*, C. Ajja, M. Wille and L. Jiang. (2014). Gene expression profiling of Drosophila tracheal fusion cells. Gene Expression Patterns 15:112-23. DOI:  10.1016/j.gep.2014.05.004.

Long, S.K., E. Fulkerson, R. Breese, G. Hernandez, C. Davis, M.A. Melton, R.R. Chandran*, N. Butler, L. Jiang and P. Estes. (2014). A comparison of midline and tracheal gene regulation during Drosophila development. PLoS One 9:e85518. DOI:  10.1371/journal.pone.0085518.

*OU student