Department of Biological Sciences

Dodge Hall Rm 375
118 Library Dr
Rochester, MI 48309-4479
(location map)
(248) 370-3550
fax: (248) 370-4225

Sang Rhee

A head shot of Dr. Sang Rhee

Sang Rhee

Assistant Professor, Ph.D.
330 DH
Lab Location: 331 & 332 DH
Lab Phone: (248) 370-3589
FAX (248) 370-4225


BIO 4226 Immunology
BIO 5226 Immunology
BIO 5610 Advance Topics Cell Physiology


Mucosal immunology; the effects of host-gut microbial interaction on immune system regulation associated with inflammatory diseases and cancer. Molecular and biochemical aspects of immune regulation underlying the diseases and the development of preventive and therapeutic approaches in humans.

Selected Publications:

Sang Hoon Rhee NCBI publication list

Howe*, C., J. Mitchell*, S.J. Kim, E. Im and S.H. Rhee. (2019). Pten gene deletion in intestinal epithelial cells enhances susceptibility to Salmonella Typhimurium infection in mice. Journal of Microbiology 57: 1012–1018. DOI: 10.1007/s12275-019-9320-3.

Mitchell*, J., S.J. Kim, A. Seelmann, B. Veit*, B. Shepard*, E. Im, and S.H. Rhee. (2018). Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses. Biochemical Pharmacology 147:119-127. DOI: 10.1016/j.bcp.2017.11.015.

Mitchell*, J., S.J. Kim, G. Koukos, A. Seelmann, B. Veit*, B. Shepard*, S. Blumer-Schuette, H.S. Winter, D. Iliopoulos, C. Pothoulakis, E. Im and S.H. Rhee. (2018). Colonic inhibition of phosphatase and tensin homolog (Pten) increases colitogenic bacteria, causing the development of colitis in Il10-/- mice. Inflammatory Bowel Diseases 24:1718-1732. DOI:10.1093/ibd/izy124.

Howe*, C., S.J. Kim, J. Mitchell*, E. Im, Y.S. Kim, Y.S. Kim and S.H. Rhee. (2018) Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten deficient mice. Biochimica et Biophysica Acta- Molecular Basis of Disease 1864: 3746-3758. DOI: 10.1016/j.bbadis.2018.10.006.

Rhee, S.H., E.L. Ma, Y. Lee, Y. Taché, C. Pothoulakis and E. Im. (2015). Corticotropin releasing hormone and urocortin 3 stimulate vascular endothelial growth factor expression through the cAMP/CREB pathway. Journal of Biological Chemistry 290(43):26194-203. DOI: 10.1074/jbc.M115.678979.

Im, E., J. Jung, C. Pothoulakis and S.H. Rhee. (2014). Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10–/– mice. Gastroenterology 147:667-679. DOI:10.1053/j.gastro.2014.05.034.

Choi, Y.J., J. Jung, H.K. Chung, E. Im and S.H. Rhee. (2013). PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment. FASEB Journal 27:243-254. DOI:10.1096/fj.12-217596.

*Oakland University student