Department of Chemistry

Mathematics and Science Center,
Room 260
146 Library Drive
Rochester, MI 48309-4479
(location map)
(248) 370-2320
fax: 370-2321

Amitava Adhikary

Amitava Adhikary holding a microphone.
Research Associate Professor
Physical Chemistry, Radiation Chemistry of Biomolecules
246 Science and Engineering Building (Office)
230 Science and Engineering Building (Lab)
(248) 370 2094 (Lab)

Ph.D. 1998, University of Delhi

Research Interests:

  • Elucidation of the mechanistic pathways involved in direct interaction of radiation with DNA,
  • Formation of site-specific aminyl radical via dissociative electron attachment to azidotnucleosides and to their derivatives (nucleotides, oligomers etc.) as well as subsequent reactions of these aminyl radicals.
  • Elucidation of mechanisms of radiomodifying actions by minor-groove-ligands, e.g., bis-benzimidazole derivative Hoechst 33258 and its analogs
  • Elucidation of mechanisms of radiomodifying actions by nanoceria.

Recent publications:

Ma, J.; Bahry, T.; Denisov, S.; Adhikary, A.; Mostafavi, M. Quasi-free Electron-mediated Radiation Sensitization by C5-Halopyrimidines. J. Phys. Chem. A 2021, 125 (36), 7967–7975. Cover illustration

Halliwell, B.; Adhikary, A.; Dingfelder, M.; Dizdaroglu, M. Hydroxyl radical is a significant player in oxidative DNA damage in vivo. Chem. Soc. Rev. 2021.

Mudgal, M.; Dang, T. P.; Sobczak, A. J.; Lumpuy, D. A.; Dutta, P.; Ward, S.; Ward, K.; Alahmadi, M.; Kumar, A.; Sevilla, M. D.; Wnuk, S. F.; Adhikary, A. Site of Azido Substitution in the Sugar Moiety of Azidopyrimidine nucleosides Influences the Reactivity of Aminyl Radicals Formed by Dissociative Electron Attachment. J. Phys. Chem. B, 2020, 124 (50), 11357 – 11370. (Cover illustration) Featured in the twitter handle of RRS:

Verma, A.; Adhikary, A.; Woloschak, G.; Dwarakanath, B. S.; Rao, V. L. Papineni. A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management. Int. J. Radiat. Biol. 2020.

Kaczmarek, R.; Ward, S.; Debnath, D.; Jacobs, T.; Stark, A. D.; Korczyński, D.; Kumar, A.; Sevilla, M. D.; Denisov, S. A.; Shcherbakov, V.; Pernot, P.; Mostafavi, M.; Dembinski, R.; Adhikary, A. One Way Traffic:  Base-to-backbone Hole Transfer in Nucleoside Phosphorodithioates. Chem. Eur.J., 2020, 26 (43), 9495-9505. (Front cover illustration and profile)

Ma, J.; Denisov, S.; Adhikary, A.; Mostafavi, M. Comment un électron induit un dommage oxydatif dans l’ADN. l'Actualité Chimique, 2020, 450, 13 – 18.

Ma, J.; Kumar, A.; Muroya, Y.; Yamashita, S.; Sakurai, T.; Denisov, S. A.; Sevilla, M. D.; Adhikary, A.; Seki, S.; Mostafavi, M. Quasi-free electron attachment to nucleoside in solution: excited anion radical formation and its dissociation. Nature Communications2019, 10, article number: 102, pp 1-7,

Wen, Z.; Peng, J.; Tuttle, P.; Ren,Y.; Garcia, C.; Debnath, D.; Rishi, S.; Hanson, C.; Ward, S.; Kumar, A.; Liu, Y.; Zhao, W.; Glazer, P. M.; Liu, Y.; Sevilla, M. D.; Adhikary, A.; Wnuk, S. F. (2018) Electron-mediated Aminyl and Iminyl Radicals from C5-Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells. Org. Lett., 2018, 20, 7400 – 7404.

Ma, J.; Denisov, S. A.; Marignier, J-L.; Pernot, P.; Adhikary, A.; Seki, S.; Mostafavi, M. (2018) Ultrafast electron attachment and hole transfer following ionizing radiation of aqueous uridine monophosphate. J. Phys. Chem. Lett., 2018, 9, 5105 – 5109.

Ma, J.; Wang, F.; Denisov, S. A.; Adhikary, A.; Mostafavi, M. (2017) Reactivity of Prehydrated Electrons towards Nucleobases and Nucleotides in Aqueous Solution. Science Advances, 2017, 3, e1701669, DOI: 10.1126/sciadv.1701669.

For complete list of publications and cv, see his personal web page.